Richard Manderville, Canada

Richard Arnold Manderville, PhD

Department of Chemistry
Science Complex, Rm 3243
Guelph, ON, Canada N1G 2W1


  • Institution and Location, Degree, Year, Field of Study
  • Queen’s Univ., Kingston, Canada, B.Sc., 1986, Biology & Chemistry
  • Queen’s Univ., Kingston, Canada, Ph.D, 1992, Chemistry
  • Univ. of Virginia, Charlottesville, USA, Postdoc, 1995, Chemistry


Representative Publications:

  • Sproviero, M. Verwey, A.M.R.; Rankin, K.M.; Witham,A.A.; Soldatov, D.V.; Manderville, R.A.; Fekry, M.I.; Sturla, S.J.; Sharma, P.; Wetmore, S.D. Nucleic Acids Res. 2014, 42, 13405.
  • Sharma, P.; Manderville, R.A.; Wetmore, S.D. Nucleic Acids Res. 2014, 42, 11831. 
  • Sproviero, M.; Manderville, R.A. Chem. Comm. 2014, 50, 3097. 
  • Sproviero, M.; Rankin, K.M.; Witham, A.A.; Manderville, R.A. J. Org. Chem. 2014, 79, 692.
  • Sproviero, M.; Fadock, K.L.; Witham, A.A.; Manderville, R.A.; Sharma, P.; Wetmore, S.D. Chem. Sci. 2014, 5, 788.
  • Kuska, M.S.; Witham, A.A.; Sproviero, M.; Manderville, R.A.; Majdi Yazdi, M.; Sharma, P.; Wetmore, S.D. Chem. Res. Toxicol. 2013, 26, 1397. 
  • Kuska, M.S.; Majdi Yazdi, M.; Witham, A.A.; Dahlmann, H.A.; Sturla, S.J.; Wetmore, S.D.; Manderville, R.A. J. Org. Chem. 2013, 78, 7176.
  • Sharma, P.; Manderville, R.A.; Wetmore, S.D. Modeling the Conformational Preference of the Carbon-Bonded Covalent Adduct Formed upon Exposure of 2′-Deoxyguanosine to Ochratoxin A. Chem. Res. Toxicol. 2013, 26, 803–816.


Theses (Last 3 years):

  1. Aaron, A. Witham, PhD, 2014, “Structural Analysis of Detrimental Oxidative Products from Phenolic Carcinogens and Construction of Nucleotide Tools from Analogous Processes
  2. Michael Sproviero, PhD, 2014, “Characterization of Fluorescent 8-Aryl-Guanine Mimics: From Mutagenic Lesions to Probes for Aptasensor Development
  3. Florence D. Berger, MSc, 2013, “Synthesis and Properties of Duplex DNA Containing Oxygen-Linked Deoxyguanosine Adducts Derived from Phenolic Carcinogens” (Collaboration with the ETH, Zurich, Switzerland).
  4. Michael S. Kuska, MSc, 2013, “Structure and Stability of Oxygen-Linked DNA Adducts Derived From Phenolic Toxins
  5. Katherine M. Rankin, PhD, 2012, “Structure and Properties of C8-Aryl-2′-Deoxyguanosine Adducts: From Mutagenic Lesions to Conformational Probes in Duplex DNA



  1. Stacey D. Wetmore, Department of Chemistry, University of Lethbridge, Alberta, Canada
  2. Shana Sturla, Institute of Food, Nutrition and Health, ETH, Zurich, Switzerland 

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